Simultaneous CRISPR screening and spatial transcriptomics reveals intracellular, intercellular, and functional transcriptional circuits.
Binan L, Danquah S, Valakh V, Simonton B, Bezney J, Nehme R, Cleary B, Farhi SL. Cell. 2025 Apr 17;188(8):2141-2158.e18. doi: 10.1016/j.cell.2025.02.012. PMID: 38076932; PMCID: PMC10705493.

Investigating spatial gene circuits and gene-phenotype mechanisms with Perturb-FISH.
Binan L, Nat Rev Genet. 2025 May 20. doi: 10.1038/s41576-025-00857-8. PMID: 40394197.

Scalable genetic screening for regulatory circuits using compressed Perturb-seq.
Yao D, Binan L, Bezney J, Simonton B, Freedman J, Frangieh CJ, Dey K, Geiger-Schuller K, Eraslan B, Gusev A, Regev A, Cleary B. Nat Biotechnol. 2024 Aug;42(8):1282-1295. doi: 10.1038/s41587-023-01964-9. Epub 2023 Oct 23. PMID: 37872410; PMCID: PMC11035494.

Pyramidal neuron subtype diversity governs microglia states in the neocortex.
Stogsdill JA, Kim K, Binan L, Farhi SL, Levin JZ, Arlotta P. Nature. 2022 Aug;608(7924):750-756. doi: 10.1038/s41586-022-05056-7. Epub 2022 Aug 10. PMID: 35948630; PMCID: PMC10502800.

GABA-receptive microglia selectively sculpt developing inhibitory circuits.
Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell G. Cell. 2021 Jul 22;184(15):4048-4063.e32. doi: 10.1016/j.cell.2021.06.018. Epub 2021 Jul 6. Cell. 2021 Oct 28;184(22):5686. doi: 10.1016/j.cell.2021.10.009. PMID: 34233165; PMCID: PMC9122259.

Live single-cell laser tag.
Binan L, Mazzaferri J, Choquet K, Lorenzo LE, Wang YC, Affar EB, De Koninck Y, Ragoussis J, Kleinman CL, Costantino S. Nat Commun. 2016 May 20;7:11636. doi: 10.1038/ncomms11636. PMID: 27198043; PMCID: PMC4876456.